Estradiol Gel

$89.95 / MONTH

Menopause relief, supports hormonal balance

Your Effecty provider will help guide you to the best option based on your history, preferences, and symptoms.

YOUR TREATMENT INCLUDES
30 packets prescribed*
Initial Telehealth Visit
Free Expedited Shipping
Prescription + Medication
Unlimited Doctor Support
No Membership Fee

*All prescriptions made only if deemed appropriate by the prescribing provider. Product image is for visual purposes only.

Product Details

Estradiol gel is a bioidentical, FDA-approved form of estrogen used to treat symptoms of perimenopause and menopause. It comes in easy-to-use single-dose packets you apply to your inner thigh daily. No pills, no hassle — just effective hormone therapy designed to help you feel like yourself again.

  • Estradiol gel delivers transdermal estrogen directly through your skin.
  • Apply to your inner thigh once a day — it absorbs quickly and dries in 2–5 minutes.
  • The gel helps restore hormone balance, relieving menopause symptoms over time.*
  • You may start to feel better in as little as 2–4 weeks, with full benefits typically within a few months.*
BENEFITS
  • Bioidentical: Matches the estrogen your body naturally produces
  • FDA-Approved: Safe, clinically proven, and widely prescribed
  • Clean Ingredients: No dyes, peanut oil, or titanium dioxide—just pure, effective estrogen
  • Mess-Free Application: Quick-drying gel, no odor once dry
  • Consistent Dosing: Individually packaged for easy, on-the-go use
  • Cardiovascular-Friendly: Transdermal estrogen is often a better fit for those with high blood pressure, diabetes, or clotting risks
  • Whole-Body Relief: Eases hot flashes, mood swings, vaginal dryness, and more

Our clinical team will personalize your dosage and plan based on your medical history and symptoms.

EXPECTATIONS

Smooth moods, fewer hot flashes, better sleep — all from a gel that disappears in minutes and helps you feel like you again.

Do you need Progesterone too?

If you still have a uterus and you're taking systemic estrogen (like estradiol gel), progesterone is prescribed as well to help protect your uterine lining. We make it easy — oral progesterone is added for $19.95 / month to your treatment plan during your initial intake.

WHY ADD PROGESTERONE
  • Protects your uterus: Estrogen alone can thicken the uterine lining over time, increasing your risk of endometrial cancer. Progesterone helps keep things balanced.
  • Supports better sleep: Many people find progesterone has a calming effect and helps improve sleep quality.
  • Eases anxiety + mood swings: It can help smooth out emotional ups and downs.
  • Whole-hormone harmony: Estrogen and progesterone work best as a team, especially during menopause.
Goodbye symptoms, hello you.
Bioidentical hormone therapy that works with your body.
Goodbye symptoms, hello you.
Bioidentical hormone therapy that works with your body.

Feel like you again — science-backed HRT made simple and supportive.

Ask Us a Question, We're here to help!

There are multiple forms of Estradiol—how do I know which one is right for me?

Effecty offers Estradiol in two topical forms (a gel and a patch) and one oral form (a tablet). If you're starting Estradiol for the first time, one of the topical options is generally recommended.

  • If you have sensitive skin or an allergy to adhesives, the gel may be your best choice.
  • If not, it's mostly a matter of personal preference between the gel and the patch—both are effective.
  • If you’ve previously been on Estradiol and were doing well with the oral tablet, you can continue with that form.

Your Effecty provider will help guide you to the best option based on your history, preferences, and symptoms.

What is Estradiol Gel used for?

Estradiol gel treats moderate to severe perimenopause and menopause symptoms like hot flashes, vaginal dryness, and mood swings. It’s also used to manage hormone levels in women at risk for osteoporosis or other estrogen-related health issues.

How do I use it?

Just apply the full contents of one packet to your inner thigh once a day, at the same time each day. Let it dry before putting on clothes—usually in under 5 minutes.

What dosing is available for Estradiol Gel?

We offer the following strengths:

  • 0.25mg
  • 0.5mg
  • 0.75mg
  • 1mg
  • 1.25mg

If eligible, your Effecty provider will prescribe the best option based on your health history.

Is this FDA-approved?

Yes! Estradiol gel is FDA-approved and bioidentical to the estrogen your body naturally makes.

Do I need progesterone with this?

If you still have a uterus and don’t already have a hormonal IUD, you’ll need to take oral progesterone alongside estradiol to prevent endometrial thickening.

What dosing is available for progesterone tablets?

We offer the following strengths: 100mg and 200mg.
If eligible, your Effecty provider will prescribe the best option based on your health history.

When will I feel results?

Most people begin to notice symptom relief in about 2–4 weeks, but full results may take up to 3 months. Consistency is key.

Can I get help figuring out if this is right for me?

Absolutely. Fill out our online medical questionnaire, and a menopause-trained doctor will guide you to the best treatment for your symptoms and history.

The Results speak for themselves

Great experience and fast response and delivery. I have used 2 other companies before and this one has met all my needs.

Shonda Smith

Ordering from Effecty is not complicated. They have instant communication with a doctor and make it easy to follow up. They let you know when your medication has been shipped and when it reaches each location before it gets to you. I have lost 40 pounds since I started and have met my goal thanks to Effecty.

Corinne Mueller

Effecty provided an exceptional experience from start to finish. The platform is user-friendly, and the medical team’s professionalism was impressive. Treatment has been effective, with noticeable health improvements. Their commitment to customer satisfaction and nationwide accessibility truly sets them apart. Highly recommended!

Alejandra Rios

Very easy to use and docs answered all questions. Ships to you within 7-10 days every time!

Melinda Rathbone

I was skeptical at first because I didn’t see many results. After week 3 everything lined up and kicked in. I’m currently down 9 lbs… and counting! I’m also loosing inches.

Raquel Miller

Effecty makes it easy to get my Tirzepatide and the cost is amazing. Also, the ease with receiving the meds to my doorstep is amazing and fast. Packaging is great! Love the service!

Tracey Clayton

I love Effecty! They’ve elevated my Semaglutide experience with 24/7 doctor support and accessible fitness trainers. The high-quality medication, combined with affordable pricing, makes Effecty perfect for anyone seeking successful weight loss. Highly recommended!

Nicolette H.

With Effecty, the process is simple: complete a survey, have a virtual doctor’s visit, and you’re in! They’re truly setting the bar high. My second experience with GLP-1s has been seamless and enjoyable.

Fatima S.

I’m loving Effecty! Unlike other companies with confusing pricing and endless hurdles, Effecty made getting a prescription straightforward and affordable. No hoops, just a simple process and transparent pricing. So glad I made the switch!

Sarah F.