In the world of longevity and wellness, NAD+ (nicotinamide adenine dinucleotide) has emerged as a key player in the quest for healthy aging and enhanced vitality. Known for its role in cellular energy production and DNA repair, NAD+ is essential for maintaining the health of our cells and, ultimately, the health of our bodies. As we age, NAD+ levels decline, contributing to fatigue, cognitive decline, and the visible signs of aging. By replenishing NAD+ levels through supplements or IV therapy, we can combat these effects and support overall wellness.

In this blog post, we’ll explore the many benefits of NAD+, how it supports healthy aging, and what you need to know about potential side effects.

What is NAD+?

NAD+ is a coenzyme found in every living cell, and it plays a central role in energy metabolism, DNA repair, and overall cellular health. Without NAD+, our cells wouldn’t be able to produce the energy (ATP) required for normal function, and they’d struggle to repair damage caused by oxidative stress and environmental factors. NAD+ is also critical in activating sirtuins, proteins involved in regulating metabolism and promoting longevity.

However, as we get older, NAD+ levels naturally decline. This drop is associated with many of the symptoms of aging, including reduced energy, slower metabolism, and increased risk of chronic diseases.

The Benefits of NAD+ for Health and Longevity

1. Enhanced Cellular Energy Production

NAD+ is essential for converting the nutrients we eat into usable energy. It helps facilitate the chemical reactions in our mitochondria—the “powerhouses” of our cells—that produce ATP (adenosine triphosphate), the energy currency of the body. By increasing NAD+ levels, we can support efficient energy production, which leads to better physical performance, reduced fatigue, and improved overall energy levels.

• Key Benefit: Increased energy levels and improved physical endurance.

2. Promotes Healthy Aging and Longevity

Research into NAD+ has shown that it plays a crucial role in activating sirtuins, proteins that regulate cellular health and longevity. Sirtuins help protect our cells from damage, regulate inflammation, and support DNA repair processes, all of which contribute to healthy aging. By boosting NAD+ levels, we can potentially extend our healthspan—the number of years we spend in good health—and reduce the risk of age-related diseases.

• Key Benefit: Slows down the aging process and supports healthy aging at the cellular level.

3. Improved Cognitive Function

NAD+ not only supports physical energy but also mental energy. NAD+ levels are closely linked to brain health and cognitive function. By increasing NAD+, you can enhance brain energy metabolism, improve memory, and protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s. Research suggests that NAD+ may help preserve brain function and promote neuroplasticity, the brain’s ability to adapt and learn new things.

• Key Benefit: Enhances memory, cognitive clarity, and focus.

4. DNA Repair and Protection

NAD+ plays a significant role in repairing damaged DNA, which accumulates over time due to factors like UV radiation, pollution, and normal metabolic processes. When our DNA is damaged, it can lead to mutations and contribute to the development of diseases, including cancer. NAD+ activates enzymes like PARPs (poly ADP-ribose polymerases) that are responsible for repairing DNA damage, protecting against cellular dysfunction and chronic illness.

• Key Benefit: Supports DNA repair and reduces the risk of mutations and age-related diseases.

5. Boosts Metabolism and Weight Management

With age, metabolism tends to slow down, leading to weight gain and increased risk of metabolic disorders like diabetes. NAD+ is involved in regulating metabolic processes, and higher NAD+ levels have been linked to better insulin sensitivity and more efficient fat metabolism. Some studies suggest that NAD+ may even enhance the body’s ability to burn fat, which can aid in weight management and reduce the risk of obesity-related diseases.

• Key Benefit: Promotes a healthy metabolism and supports weight management.

6. Reduces Inflammation and Oxidative Stress

Chronic inflammation and oxidative stress are two key drivers of aging and disease. NAD+ helps regulate the body’s response to inflammation by supporting the production of antioxidants and activating anti-inflammatory pathways. This can reduce the overall burden of oxidative stress on the body, promoting a healthier, longer life.

• Key Benefit: Reduces inflammation and protects against oxidative damage.

How to Boost NAD+ Levels

There are several ways to increase NAD+ levels, including:

• NAD+ Precursors: Supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) can boost NAD+ production in the body.
• IV NAD+ Therapy or Injections: Direct NAD+ infusions can bypass digestion and deliver the coenzyme directly to cells, offering faster, more effective results.
• Lifestyle Choices: Intermittent fasting, exercise, and a balanced diet rich in nutrients can naturally support NAD+ levels.

Potential Side Effects of NAD+ Supplementation

While NAD+ supplementation offers numerous benefits, it’s essential to be aware of potential side effects, particularly with higher doses or IV therapy. Most people tolerate NAD+ precursors and supplements well, but some side effects can occur, including:

• Nausea: Some people report mild nausea or digestive discomfort after taking NAD+ supplements or receiving IV therapy.
• Fatigue: While NAD+ generally improves energy, some people experience temporary fatigue after taking supplements or undergoing treatment. This may be due to the body’s increased demand for NAD+ as it ramps up energy production and repair processes.
• Headaches: A small percentage of users report mild headaches after taking NAD+ supplements.
• Flushing or Sweating: Some people experience a temporary feeling of warmth or flushing, particularly with IV NAD+ therapy.

It’s important to start with a lower dose of NAD+ and gradually increase it under the guidance of a healthcare professional to minimize potential side effects. For individuals with existing medical conditions or those taking other medications, it’s advisable to consult a healthcare provider before starting NAD+ supplementation.

Conclusion: NAD+ for a Healthier, Longer Life

NAD+ is a critical molecule for cellular energy, DNA repair, and overall health. As we age and NAD+ levels decline, we become more vulnerable to fatigue, cognitive decline, and age-related diseases. By boosting NAD+ levels through supplementation or IV therapy, you can support healthy aging, enhance cognitive function, improve metabolism, and reduce inflammation.

While NAD+ offers powerful benefits for longevity and vitality, it’s essential to approach supplementation with care, considering any potential side effects and working with a healthcare provider to determine the best course of action for your individual health needs.

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This smoothie combines the sweetness of peaches with the goodness of greens and filling ingredients, perfect for a satisfying and nutritious boost in Aspen's summer.

Yields: 1 serving
Prep time: 5 minutes

INGREDIENTS

Liquid Base:

• 1 cup unsweetened almond milk (or other unsweetened plant-based milk) - Keeps the carb count low.

Protein Powerhouse:

• 1 scoop unflavored or vanilla protein powder (whey, pea, or hemp, low-sugar) - Crucial for satiety and muscle support.
• 1/2 cup plain Greek yogurt (unsweetened, full-fat or 2%) - Adds creaminess, more protein, and beneficial probiotics.

Fiber & Antioxidant Rich Fruits/Veggies:

• 1 medium peach, fresh or frozen (peeled and pitted if fresh) - The star of the show! Provides natural sweetness and fiber.
• 1 cup fresh spinach or baby kale - Packs in vitamins, minerals, and fiber without a strong taste, especially with the peach.

Healthy Fats & Extra Fiber:

• 1 tablespoon flax seeds (ground for better absorption, or whole) - Excellent source of fiber, lignans, and omega-3 fatty acids.
• 1 tablespoon almond butter (unsweetened, natural) - Adds healthy fats, protein, and a rich, nutty flavor.

Optional Boosts:

• 1/4 teaspoon ground ginger - Complements the peach flavor beautifully and has anti-inflammatory properties.
• A few drops of liquid stevia or monk fruit (if you prefer more sweetness, but taste first!) - For natural, zero-calorie sweetness.
• Ice cubes (if using fresh peach and you want it colder/thicker)

Instructions:

1. Place the almond milk, protein powder, Greek yogurt, peach, spinach/kale, flax seeds, and almond butter into a high-speed blender.
2. Add any optional boosts like ginger or stevia now.
3. Blend until completely smooth and creamy. If you're using fresh peach and want it colder, add a few ice cubes and blend again until smooth.
4. Pour into your favorite glass and enjoy this refreshing and filling summer smoothie!

Why this works for GLP-1:

• High Protein: Greek yogurt and protein powder provide a significant protein punch, which is key for signaling satiety.
• Rich in Fiber: Peach, spinach/kale, and flax seeds contribute ample fiber, slowing digestion and helping to stabilize blood sugar.
• Healthy Fats: Almond butter and the fats from Greek yogurt provide sustained energy and contribute to feeling full.
• Low Glycemic: While peaches have natural sugars, they are paired with plenty of fiber and protein to prevent a rapid blood sugar spike. Using greens also helps balance the sugar content.
• Refreshing: The peach and optional ginger make this a delightful summer treat!

Join our one of our founders, Sam, for a 20 minute arm workout at home! You do not need weights, let's use what you have at home and get moving!